Pathogenic Tau Impairs Axon Initial Segment Plasticity and Excitability Homeostasis

Dysregulation of neuronal excitability underlies the pathogenesis of tauopathies, including frontotemporal dementia (FTD) with tau inclusions. A majority of FTD-causing tau mutations are located in the microtubule-binding domain, but how these mutations alter neuronal excitability is largely unknown...

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Veröffentlicht in:Neuron
Hauptverfasser: Sohn, Peter Dongmin, Huang, Cindy Tzu-Ling, Yan, Rui, Fan, Li, Tracy, Tara E., Camargo, Carolina M., Montgomery, Kelly M., Arhar, Taylor, Mok, Sue-Ann, Freilich, Rebecca, Baik, Justin, He, Manni, Gong, Shiaoching, Roberson, Erik D., Karch, Celeste M., Gestwicki, Jason E., Xu, Ke, Kosik, Kenneth S., Gan, Li
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2019
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6880876/
https://ncbi.nlm.nih.gov/pubmed/31542321
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuron.2019.08.008
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