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Opposing actions of renal tubular- and myeloid-derived porcupine in obstruction-induced kidney fibrosis.
Wnt/β-catenin signaling is essential in the pathogenesis of renal fibrosis. We previously reported inhibition of the Wnt O-acyl transferase porcupine, required for Wnt secretion, dramatically attenuates kidney fibrosis in the murine unilateral ureteral obstruction model. Here, we investigated the ti...
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| Pubblicato in: | Kidney Int |
|---|---|
| Autori principali: | , , , , , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2019
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6875628/ https://ncbi.nlm.nih.gov/pubmed/31585741 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.kint.2019.06.020 |
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