Opposing actions of renal tubular- and myeloid-derived porcupine in obstruction-induced kidney fibrosis.

Wnt/β-catenin signaling is essential in the pathogenesis of renal fibrosis. We previously reported inhibition of the Wnt O-acyl transferase porcupine, required for Wnt secretion, dramatically attenuates kidney fibrosis in the murine unilateral ureteral obstruction model. Here, we investigated the ti...

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Detalhes bibliográficos
Publicado no:Kidney Int
Main Authors: Lu, Xiaohan, Rudemiller, Nathan P., Ren, Jiafa, Wen, Yi, Yang, Bo, Griffiths, Robert, Privratsky, Jamie R., Madan, Babita, Virshup, David M, Crowley, Steven D
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6875628/
https://ncbi.nlm.nih.gov/pubmed/31585741
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.kint.2019.06.020
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