A small-molecule competitive inhibitor of phosphatidic acid binding by the AAA+ protein NSF/Sec18 blocks the SNARE-priming stage of vacuole fusion

The homeostasis of most organelles requires membrane fusion mediated by soluble N-ethylmaleimide–sensitive factor (NSF) attachment protein receptors (SNAREs). SNAREs undergo cycles of activation and deactivation as membranes move through the fusion cycle. At the top of the cycle, inactive cis-SNARE...

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Опубликовано в: :J Biol Chem
Главные авторы: Sparks, Robert P., Arango, Andres S., Starr, Matthew L., Aboff, Zachary L., Hurst, Logan R., Rivera-Kohr, David A., Zhang, Chi, Harnden, Kevin A., Jenkins, Jermaine L., Guida, Wayne C., Tajkhorshid, Emad, Fratti, Rutilio A.
Формат: Artigo
Язык:Inglês
Опубликовано: American Society for Biochemistry and Molecular Biology 2019
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC6873166/
https://ncbi.nlm.nih.gov/pubmed/31515268
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA119.008865
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