Phosphatidic acid induces conformational changes in Sec18 protomers that prevent SNARE priming

Eukaryotic cell homeostasis requires transfer of cellular components among organelles and relies on membrane fusion catalyzed by SNARE proteins. Inactive SNARE bundles are reactivated by hexameric N-ethylmaleimide-sensitive factor, vesicle-fusing ATPase (Sec18/NSF)-driven disassembly that enables a...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Starr, Matthew L., Sparks, Robert P., Arango, Andres S., Hurst, Logan R., Zhao, Zhiyu, Lihan, Muyun, Jenkins, Jermaine L., Tajkhorshid, Emad, Fratti, Rutilio A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2019
Assuntos:
Cell Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6398130/
https://ncbi.nlm.nih.gov/pubmed/30617180
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.006552
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