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Phosphatidic acid sequesters Sec18p from cis-SNARE complexes to inhibit priming

Yeast vacuole fusion requires the activation of cis-SNARE complexes through priming carried out by Sec18p/NSF and Sec17p/α-SNAP. The association of Sec18p with vacuolar cis-SNAREs is regulated in part by phosphatidic acid (PA) phosphatase production of diacylglycerol (DAG). Inhibition of PA phosphat...

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Detalhes bibliográficos
Publicado no:Traffic
Main Authors: Starr, Matthew L., Hurst, Logan R., Fratti, Rutilio A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5023487/
https://ncbi.nlm.nih.gov/pubmed/27364524
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/tra.12423
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