Developmental Toxicity Assessment of Piperonyl Butoxide Exposure Targeting Sonic Hedgehog Signaling and Forebrain and Face Morphogenesis in the Mouse: An in Vitro and in Vivo Study

BACKGROUND: Piperonyl butoxide (PBO) is a pesticide synergist used in residential, commercial, and agricultural settings. PBO was recently found to inhibit Sonic hedgehog (Shh) signaling, a key developmental regulatory pathway. Disruption of Shh signaling is linked to birth defects, including holopr...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Julkaisussa:Environ Health Perspect
Päätekijät: Everson, Joshua L., Sun, Miranda R., Fink, Dustin M., Heyne, Galen W., Melberg, Cal G., Nelson, Kia F., Doroodchi, Padydeh, Colopy, Lydia J., Ulschmid, Caden M., Martin, Alexander A., McLaughlin, Matthew T., Lipinski, Robert J.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Environmental Health Perspectives 2019
Aiheet:
Research
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC6867268/
https://ncbi.nlm.nih.gov/pubmed/31642701
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1289/EHP5260
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