Developmental Toxicity Assessment of Piperonyl Butoxide Exposure Targeting Sonic Hedgehog Signaling and Forebrain and Face Morphogenesis in the Mouse: An in Vitro and in Vivo Study

BACKGROUND: Piperonyl butoxide (PBO) is a pesticide synergist used in residential, commercial, and agricultural settings. PBO was recently found to inhibit Sonic hedgehog (Shh) signaling, a key developmental regulatory pathway. Disruption of Shh signaling is linked to birth defects, including holopr...

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Detalhes bibliográficos
Publicado no:Environ Health Perspect
Main Authors: Everson, Joshua L., Sun, Miranda R., Fink, Dustin M., Heyne, Galen W., Melberg, Cal G., Nelson, Kia F., Doroodchi, Padydeh, Colopy, Lydia J., Ulschmid, Caden M., Martin, Alexander A., McLaughlin, Matthew T., Lipinski, Robert J.
Formato: Artigo
Idioma:Inglês
Publicado em: Environmental Health Perspectives 2019
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6867268/
https://ncbi.nlm.nih.gov/pubmed/31642701
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1289/EHP5260
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