Developmental Toxicity Assessment of Piperonyl Butoxide Exposure Targeting Sonic Hedgehog Signaling and Forebrain and Face Morphogenesis in the Mouse: An in Vitro and in Vivo Study

BACKGROUND: Piperonyl butoxide (PBO) is a pesticide synergist used in residential, commercial, and agricultural settings. PBO was recently found to inhibit Sonic hedgehog (Shh) signaling, a key developmental regulatory pathway. Disruption of Shh signaling is linked to birth defects, including holopr...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Environ Health Perspect
Prif Awduron: Everson, Joshua L., Sun, Miranda R., Fink, Dustin M., Heyne, Galen W., Melberg, Cal G., Nelson, Kia F., Doroodchi, Padydeh, Colopy, Lydia J., Ulschmid, Caden M., Martin, Alexander A., McLaughlin, Matthew T., Lipinski, Robert J.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Environmental Health Perspectives 2019
Pynciau:
Research
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC6867268/
https://ncbi.nlm.nih.gov/pubmed/31642701
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1289/EHP5260
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