Developmental Toxicity Assessment of Piperonyl Butoxide Exposure Targeting Sonic Hedgehog Signaling and Forebrain and Face Morphogenesis in the Mouse: An in Vitro and in Vivo Study

BACKGROUND: Piperonyl butoxide (PBO) is a pesticide synergist used in residential, commercial, and agricultural settings. PBO was recently found to inhibit Sonic hedgehog (Shh) signaling, a key developmental regulatory pathway. Disruption of Shh signaling is linked to birth defects, including holopr...

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Bibliografische gegevens
Gepubliceerd in:Environ Health Perspect
Hoofdauteurs: Everson, Joshua L., Sun, Miranda R., Fink, Dustin M., Heyne, Galen W., Melberg, Cal G., Nelson, Kia F., Doroodchi, Padydeh, Colopy, Lydia J., Ulschmid, Caden M., Martin, Alexander A., McLaughlin, Matthew T., Lipinski, Robert J.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Environmental Health Perspectives 2019
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Research
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6867268/
https://ncbi.nlm.nih.gov/pubmed/31642701
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1289/EHP5260
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