Definition of Critical Periods for Hedgehog Pathway Antagonist-Induced Holoprosencephaly, Cleft Lip, and Cleft Palate

The Hedgehog (Hh) signaling pathway mediates multiple spatiotemporally-specific aspects of brain and face development. Genetic and chemical disruptions of the pathway are known to result in an array of structural malformations, including holoprosencephaly (HPE), clefts of the lip with or without cle...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Heyne, Galen W., Melberg, Cal G., Doroodchi, Padydeh, Parins, Kia F., Kietzman, Henry W., Everson, Joshua L., Ansen-Wilson, Lydia J., Lipinski, Robert J.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2015
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4368540/
https://ncbi.nlm.nih.gov/pubmed/25793997
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0120517
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