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Cleft lip and palate results from Hedgehog signaling antagonism in the mouse: phenotypic characterization and clinical implications
BACKGROUND: The Hedgehog (Hh) pathway provides inductive signals critical for developmental patterning of the brain and face. In humans as well as in animal model systems, interference with this pathway yields birth defects; among the most well-studied of which fall within the holoprosencephaly (HPE...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2922848/ https://ncbi.nlm.nih.gov/pubmed/20213699 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/bdra.20656 |
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