Definition of Critical Periods for Hedgehog Pathway Antagonist-Induced Holoprosencephaly, Cleft Lip, and Cleft Palate

The Hedgehog (Hh) signaling pathway mediates multiple spatiotemporally-specific aspects of brain and face development. Genetic and chemical disruptions of the pathway are known to result in an array of structural malformations, including holoprosencephaly (HPE), clefts of the lip with or without cle...

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Vydáno v:PLoS One
Hlavní autoři: Heyne, Galen W., Melberg, Cal G., Doroodchi, Padydeh, Parins, Kia F., Kietzman, Henry W., Everson, Joshua L., Ansen-Wilson, Lydia J., Lipinski, Robert J.
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2015
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4368540/
https://ncbi.nlm.nih.gov/pubmed/25793997
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0120517
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