Sonic hedgehog regulation of Foxf2 promotes cranial neural crest mesenchyme proliferation and is disrupted in cleft lip morphogenesis

Cleft lip is one of the most common human birth defects, yet our understanding of the mechanisms that regulate lip morphogenesis is limited. Here, we show in mice that sonic hedgehog (Shh)-induced proliferation of cranial neural crest cell (cNCC) mesenchyme is required for upper lip closure. Gene ex...

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Bibliografische gegevens
Gepubliceerd in:Development
Hoofdauteurs: Everson, Joshua L., Fink, Dustin M., Yoon, Joon Won, Leslie, Elizabeth J., Kietzman, Henry W., Ansen-Wilson, Lydia J., Chung, Hannah M., Walterhouse, David O., Marazita, Mary L., Lipinski, Robert J.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: The Company of Biologists Ltd 2017
Onderwerpen:
Research Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5482988/
https://ncbi.nlm.nih.gov/pubmed/28506991
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/dev.149930
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