Sonic hedgehog regulation of Foxf2 promotes cranial neural crest mesenchyme proliferation and is disrupted in cleft lip morphogenesis

Cleft lip is one of the most common human birth defects, yet our understanding of the mechanisms that regulate lip morphogenesis is limited. Here, we show in mice that sonic hedgehog (Shh)-induced proliferation of cranial neural crest cell (cNCC) mesenchyme is required for upper lip closure. Gene ex...

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Detalhes bibliográficos
Publicado no:Development
Main Authors: Everson, Joshua L., Fink, Dustin M., Yoon, Joon Won, Leslie, Elizabeth J., Kietzman, Henry W., Ansen-Wilson, Lydia J., Chung, Hannah M., Walterhouse, David O., Marazita, Mary L., Lipinski, Robert J.
Formato: Artigo
Idioma:Inglês
Publicado em: The Company of Biologists Ltd 2017
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5482988/
https://ncbi.nlm.nih.gov/pubmed/28506991
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/dev.149930
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