Sonic hedgehog regulation of Foxf2 promotes cranial neural crest mesenchyme proliferation and is disrupted in cleft lip morphogenesis

Cleft lip is one of the most common human birth defects, yet our understanding of the mechanisms that regulate lip morphogenesis is limited. Here, we show in mice that sonic hedgehog (Shh)-induced proliferation of cranial neural crest cell (cNCC) mesenchyme is required for upper lip closure. Gene ex...

Full description

Saved in:
Bibliographic Details
Published in:Development
Main Authors: Everson, Joshua L., Fink, Dustin M., Yoon, Joon Won, Leslie, Elizabeth J., Kietzman, Henry W., Ansen-Wilson, Lydia J., Chung, Hannah M., Walterhouse, David O., Marazita, Mary L., Lipinski, Robert J.
Format: Artigo
Language:Inglês
Published: The Company of Biologists Ltd 2017
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5482988/
https://ncbi.nlm.nih.gov/pubmed/28506991
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/dev.149930
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items