SLX4IP Antagonizes Promiscuous BLM Activity during ALT Maintenance

Cancer cells acquire unlimited proliferative capacity by either re-expressing telomerase or inducing alternative lengthening of telomeres (ALT), which relies on telomere recombination. Here, we show that ALT recombination requires coordinate regulation of the SMX and BTR complexes to ensure the appr...

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Detalhes bibliográficos
Publicado no:Mol Cell
Main Authors: Panier, Stephanie, Maric, Marija, Hewitt, Graeme, Mason-Osann, Emily, Gali, Himabindu, Dai, Anqi, Labadorf, Adam, Guervilly, Jean-Hugues, Ruis, Philip, Segura-Bayona, Sandra, Belan, Ondrej, Marzec, Paulina, Gaillard, Pierre-Henri L., Flynn, Rachel L., Boulton, Simon J.
Formato: Artigo
Idioma:Inglês
Publicado em: Cell Press 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6863466/
https://ncbi.nlm.nih.gov/pubmed/31447390
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2019.07.010
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