Identification of a novel gene fusion in ALT positive osteosarcoma

The Alternative Lengthening of Telomeres (ALT) pathway stimulates telomere elongation and prevents cellular senescence in approximately 60% of osteosarcoma. While the precise mechanism underlying activation of the ALT pathway is unclear, mutations in the chromatin remodeling protein ATRX, histone ch...

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Vydáno v:Oncotarget
Hlavní autoři: Mason-Osann, Emily, Dai, Anqi, Floro, Jess, Lock, Ying Jie, Reiss, Matthew, Gali, Himabindu, Matschulat, Adeline, Labadorf, Adam, Flynn, Rachel Litman
Médium: Artigo
Jazyk:Inglês
Vydáno: Impact Journals LLC 2018
Témata:
Research Paper
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6132345/
https://ncbi.nlm.nih.gov/pubmed/30214690
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.26029
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