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G-quadruplex Stabilization Fuels the ALT Pathway in ALT-positive Osteosarcoma Cells
Most human tumors maintain telomere lengths by telomerase, whereas a portion of them (10–15%) uses a mechanism named alternative lengthening of telomeres (ALT). The telomeric G-quadruplex (G4) ligand RHPS4 is known for its potent antiproliferative effect, as shown in telomerase-positive cancer model...
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| Publicado no: | Genes (Basel) |
|---|---|
| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
MDPI
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7140816/ https://ncbi.nlm.nih.gov/pubmed/32183119 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/genes11030304 |
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