G-quadruplex Stabilization Fuels the ALT Pathway in ALT-positive Osteosarcoma Cells

Most human tumors maintain telomere lengths by telomerase, whereas a portion of them (10–15%) uses a mechanism named alternative lengthening of telomeres (ALT). The telomeric G-quadruplex (G4) ligand RHPS4 is known for its potent antiproliferative effect, as shown in telomerase-positive cancer model...

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Detaylı Bibliyografya
Yayımlandı:Genes (Basel)
Asıl Yazarlar: Amato, Roberta, Valenzuela, Martina, Berardinelli, Francesco, Salvati, Erica, Maresca, Carmen, Leone, Stefano, Antoccia, Antonio, Sgura, Antonella
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: MDPI 2020
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC7140816/
https://ncbi.nlm.nih.gov/pubmed/32183119
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/genes11030304
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