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Transient ALT activation protects human primary cells from chromosome instability induced by low chronic oxidative stress
Cells are often subjected to the effect of reactive oxygen species (ROS) as a result of both intracellular metabolism and exposure to exogenous factors. ROS-dependent oxidative stress can induce 8-oxodG within the GGG triplet found in the G-rich human telomeric sequence (TTAGGG), making telomeres hi...
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| Publicado no: | Sci Rep |
|---|---|
| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5327399/ https://ncbi.nlm.nih.gov/pubmed/28240303 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep43309 |
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