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Oxidative Stress Induces Telomere Dysfunction and Senescence by Replication Fork Arrest

Oxidative DNA damage, particularly 8-oxoguanine, represents the most frequent DNA damage in human cells, especially at the telomeric level. The presence of oxidative lesions in the DNA can hinder the replication fork and is able to activate the DNA damage response. In this study, we wanted to unders...

Täydet tiedot

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Bibliografiset tiedot
Julkaisussa:Cells
Päätekijät: Coluzzi, Elisa, Leone, Stefano, Sgura, Antonella
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: MDPI 2019
Aiheet:
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC6356380/
https://ncbi.nlm.nih.gov/pubmed/30609792
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cells8010019
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