Telomerase abrogates aneuploidy-induced telomere replication stress, senescence and cell depletion

The causal role of aneuploidy in cancer initiation remains under debate since mutations of euploidy-controlling genes reduce cell fitness but aneuploidy strongly associates with human cancers. Telomerase activation allows immortal growth by stabilizing telomere length, but its role in aneuploidy sur...

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Detalhes bibliográficos
Publicado no:EMBO J
Main Authors: Meena, Jitendra K, Cerutti, Aurora, Beichler, Christine, Morita, Yohei, Bruhn, Christopher, Kumar, Mukesh, Kraus, Johann M, Speicher, Michael R, Wang, Zhao-Qi, Kestler, Hans A, d’Adda di Fagagna, Fabrizio, Günes, Cagatay, Rudolph, Karl Lenhard
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley & Sons, Ltd 2015
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4491997/
https://ncbi.nlm.nih.gov/pubmed/25820263
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embj.201490070
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