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Telomerase abrogates aneuploidy-induced telomere replication stress, senescence and cell depletion
The causal role of aneuploidy in cancer initiation remains under debate since mutations of euploidy-controlling genes reduce cell fitness but aneuploidy strongly associates with human cancers. Telomerase activation allows immortal growth by stabilizing telomere length, but its role in aneuploidy sur...
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Опубликовано в: : | EMBO J |
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Главные авторы: | , , , , , , , , , , , , |
Формат: | Artigo |
Язык: | Inglês |
Опубликовано: |
John Wiley & Sons, Ltd
2015
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Предметы: | |
Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4491997/ https://ncbi.nlm.nih.gov/pubmed/25820263 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embj.201490070 |
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