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Synthesis and μ-Opioid Activity of the Primary Metabolites of Carfentanil

[Image: see text] Carfentanil is a synthetic opioid significantly more potent than clinically prescribed fentanyl. The primary metabolites of carfentanil, generated from human liver microsomes, were structurally confirmed through chemical synthesis. The synthesized compounds were evaluated for μ-opi...

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Detalhes bibliográficos
Publicado no:ACS Med Chem Lett
Main Authors: Hsu, Fu-Lian, Walz, Andrew J., Myslinski, James M., Kong, Li, Feasel, Michael G., Goralski, Tyler D. P., Rose, Tim, Cooper, Nicholas J., Roughley, Neil, Timperley, Christopher M.
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2019
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6862335/
https://ncbi.nlm.nih.gov/pubmed/31749912
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.9b00404
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