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‘Carba’-carfentanil (trans isomer): a μ opioid receptor (MOR) partial agonist with a distinct binding mode
There is strong evidence to indicate that a positively charged nitrogen of endogenous and exogenous opioid ligands forms a salt bridge with the Asp residue in the third transmembrane helix of opioid receptors. To further examine the role of this electrostatic interaction in opioid receptor binding a...
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| Main Authors: | , , , , , |
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| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
2014
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4149825/ https://ncbi.nlm.nih.gov/pubmed/25129170 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2014.07.033 |
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