Bifunctional μ/δ Opioid Peptides: Variation of the Type and Length of the Linker Connecting the Two Components

Por Ding, Jinguo, Lemieux, Carole, Chung, Nga N., Schiller, Peter W.
Publicado em 2012

Novel TIPP (H-Tyr-Tic-Phe-Phe-OH) analogues displaying a wide range of efficacies at the δ opioid receptor. Discovery of two highly potent and selective δ opioid agonists

Por Berezowska, Irena, Lemieux, Carole, Chung, Nga N., Ding, Jinguo, Schiller, Peter W.
Publicado em 2012

Dicarba Analogues of the Cyclic Enkephalin Peptides H-Tyr-c[D-Cys-Gly-Phe-D(or L)-Cys]NH(2) Retain High Opioid Activity

Por Berezowska, Irena, Chung, Nga N., Lemieux, Carole, Wilkes, Brian C., Schiller, Peter W.
Publicado em 2007

Stereoselective Synthesis of (3S)- and (3R)-3-Hydroxy-3-(2,6-Dimethyl-4-Hydroxyphenyl)Propanoic Acid and its Incorporation into a Cyclic Enkephalin Analogue

Por Weltrowska, Grazyna, Lemieux, Carole, Chung, Nga N., Wilkes, Brian C., Schiller, Peter W.
Publicado em 2009

Cyclic Opioid Peptide Agonists and Antagonists Obtained Via Ring-Closing Metathesis

Por Berezowska, Irena, Lemieux, Carole, Chung, Nga N., Wilkes, Brian C., Schiller, Peter W.
Publicado em 2009

Agonist vs Antagonist Behavior of δ Opioid Peptides Containing Novel Phenylalanine Analogues in Place of Tyr(1)

Por Berezowska, Irena, Chung, Nga N., Lemieux, Carole, Wilkes, Brian C., Schiller, Peter W.
Publicado em 2009

N-Methylated Cyclic Enkephalin Analogues Retain High Opioid Receptor Binding Affinity

Por Weltrowska, Grazyna, Berezowska, Irena, Lemieux, Carole, Chung, Nga N., Wilkes, Brian C., Schiller, Peter W.
Publicado em 2009

‘Carba’-carfentanil (trans isomer): a μ opioid receptor (MOR) partial agonist with a distinct binding mode

Por Weltrowska, Grazyna, Lemieux, Carole, Chung, Nga N., Guo, Jason J., Wilkes, Brian C., Schiller, Peter W.
Publicado em 2014

‘Carba’-Analogues of Fentanyl are Opioid Receptor Agonists

Por Weltrowska, Grazyna, Chung, Nga N., Lemieux, Carole, Guo, Jianxin, Lu, Yixin, Wilkes, Brian C., Schiller, Peter W.
Publicado em 2010

Novel Opioid Peptide Derived Antagonists Containing (2S)-2-Methyl-3-(2,6-dimethyl-4-carbamoylphenyl)propanoic Acid [(2S)-Mdcp]

Por Ghosh, Animesh, Luo, Jie, Liu, Chen, Weltrowska, Grazyna, Lemieux, Carole, Chung, Nga N., Lu, Yixin, Schiller, Peter W.
Publicado em 2008

Design of novel neurokinin 1 receptor antagonists based on conformationally constrained aromatic amino acids and discovery of a potent chimeric opioid agonist-neurokinin 1 receptor...

Por Ballet, Steven, Feytens, Debby, Buysse, Koen, Chung, Nga N., Lemieux, Carole, Tumati, Suneeta, Keresztes, Attila, Van Duppen, Joost, Lai, Josephine, Varga, Eva, Porreca, Frank, Schiller, Peter W., Broeck, Jozef Vanden, Tourwé, Dirk
Publicado em 2011

Variation of the net charge, lipophilicity and side chain flexibility in Dmt(1)-DALDA: effect on opioid activity and biodistribution

Por Novoa, Alexandre, Van Dorpe, Sylvia, Wynendaele, Evelien, Spetea, Mariana, Bracke, Nathalie, Stalmans, Sofie, Betti, Cecilia, Chung, Nga N., Lemieux, Carole, Zuegg, Johannes, Cooper, Matthew A., Tourwé, Dirk, De Spiegeleer, Bart, Schiller, Peter W., Ballet, Steven
Publicado em 2012

Analgesic Properties of Opioid/NK1 Multitarget Ligands with Distinct in Vitro Profiles in Naive and Chronic Constriction Injury Mice

Por Starnowska, Joanna, Costante, Roberto, Guillemyn, Karel, Popiolek-Barczyk, Katarzyna, Chung, Nga N., Lemieux, Carole, Keresztes, Attila, Van Duppen, Joost, Mollica, Adriano, Streicher, John, Broeck, Jozef Vanden, Schiller, Peter W., Tourwé, Dirk, Mika, Joanna, Ballet, Steven, Przewlocka, Barbara
Publicado no ACS Chem Neurosci (2017)

Synthesis and biological evaluation of compact, conformationally constrained bifunctional opioid agonist – neurokinin-1 antagonist peptidomimetics

Por Guillemyn, Karel, Kleczkowska, Patrycia, Lesniak, Anna, Dyniewicz, Jolanta, Van der Poorten, Olivier, Van den Eynde, Isabelle, Keresztes, Attila, Varga, Eva, Lai, Josephine, Porreca, Frank, Chung, Nga N., Lemieux, Carole, Mika, Joanna, Rojewska, Ewelina, Makuch, Wioletta, Van Duppen, Joost, Przewlocka, Barbara, Broeck, Jozef Vanden, Lipkowski, Andrzej W., Schiller, Peter W., Tourwé, Dirk, Ballet, Steven
Publicado no Eur J Med Chem (2014)