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‘Carba’-Analogues of Fentanyl are Opioid Receptor Agonists

There is evidence to indicate that the Asp residue in the third transmembrane helix (TMH) of opioid receptors forms a salt bridge with the positively charged nitrogen of endogenous and exogenous opioid ligands. To further examine the role of this electrostatic interaction in receptor binding and act...

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Detalhes bibliográficos
Main Authors: Weltrowska, Grazyna, Chung, Nga N., Lemieux, Carole, Guo, Jianxin, Lu, Yixin, Wilkes, Brian C., Schiller, Peter W.
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2848705/
https://ncbi.nlm.nih.gov/pubmed/20218625
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm9019068
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