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Equipotent enantiomers of cyclic opioid peptides at μ opioid receptor
Head-to-tail cyclized analogues of the μ opioid receptor (MOR) agonist tetrapeptides DALDA (H-Tyr-D-Arg-Phe-Lys-NH(2) and [Dmt(1)]DALDA (H-Dmt-D-Arg-Phe-Lys-NH(2); Dmt = 2′,6′-dimethyltyrosine) and their enantiomers (mirror-image isomers) were synthesized and pharmacologically characterized in vitro...
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| Publicado no: | Pept Sci (Hoboken) |
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| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6383560/ https://ncbi.nlm.nih.gov/pubmed/30801053 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pep2.24078 |
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