Equipotent enantiomers of cyclic opioid peptides at μ opioid receptor

Head-to-tail cyclized analogues of the μ opioid receptor (MOR) agonist tetrapeptides DALDA (H-Tyr-D-Arg-Phe-Lys-NH(2) and [Dmt(1)]DALDA (H-Dmt-D-Arg-Phe-Lys-NH(2); Dmt = 2′,6′-dimethyltyrosine) and their enantiomers (mirror-image isomers) were synthesized and pharmacologically characterized in vitro...

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Bibliographic Details
Published in:Pept Sci (Hoboken)
Main Authors: Weltrowska, Grazyna, Nguyen, Thi M.-D., Chung, Nga N., Wilkes, Brian C., Schiller, Peter W.
Format: Artigo
Language:Inglês
Published: 2018
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6383560/
https://ncbi.nlm.nih.gov/pubmed/30801053
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pep2.24078
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