Analgesic Properties of Opioid/NK1 Multitarget Ligands with Distinct in Vitro Profiles in Naive and Chronic Constriction Injury Mice

The lower efficacy of opioids in neuropathic pain may be due to the increased activity of pronociceptive systems such as substance P. We present evidence to support this hypothesis in this work from the spinal cord in a neuropathic pain model in mice. Biochemical analysis confirmed the elevated mRNA...

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Vydáno v:ACS Chem Neurosci
Hlavní autoři: Starnowska, Joanna, Costante, Roberto, Guillemyn, Karel, Popiolek-Barczyk, Katarzyna, Chung, Nga N., Lemieux, Carole, Keresztes, Attila, Van Duppen, Joost, Mollica, Adriano, Streicher, John, Broeck, Jozef Vanden, Schiller, Peter W., Tourwé, Dirk, Mika, Joanna, Ballet, Steven, Przewlocka, Barbara
Médium: Artigo
Jazyk:Inglês
Vydáno: 2017
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5647227/
https://ncbi.nlm.nih.gov/pubmed/28699350
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschemneuro.7b00226
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