Analgesic Properties of Opioid/NK1 Multitarget Ligands with Distinct in Vitro Profiles in Naive and Chronic Constriction Injury Mice

The lower efficacy of opioids in neuropathic pain may be due to the increased activity of pronociceptive systems such as substance P. We present evidence to support this hypothesis in this work from the spinal cord in a neuropathic pain model in mice. Biochemical analysis confirmed the elevated mRNA...

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Gepubliceerd in:ACS Chem Neurosci
Hoofdauteurs: Starnowska, Joanna, Costante, Roberto, Guillemyn, Karel, Popiolek-Barczyk, Katarzyna, Chung, Nga N., Lemieux, Carole, Keresztes, Attila, Van Duppen, Joost, Mollica, Adriano, Streicher, John, Broeck, Jozef Vanden, Schiller, Peter W., Tourwé, Dirk, Mika, Joanna, Ballet, Steven, Przewlocka, Barbara
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2017
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5647227/
https://ncbi.nlm.nih.gov/pubmed/28699350
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschemneuro.7b00226
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