TRPV1 is a physiological regulator of μ-opioid receptors

Opioids are powerful analgesics, but also carry significant side effects and abuse potential. Here we describe a modulator of the μ-opioid receptor (MOR1), the transient receptor potential channel subfamily vanilloid member 1 (TRPV1). We show that TRPV1 binds MOR1 and blocks opioid-dependent phospho...

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Publicado en:Proc Natl Acad Sci U S A
Autores principales: Scherer, Paul C., Zaccor, Nicholas W., Neumann, Neil M., Vasavda, Chirag, Barrow, Roxanne, Ewald, Andrew J., Rao, Feng, Sumner, Charlotte J., Snyder, Solomon H.
Formato: Artigo
Lenguaje:Inglês
Publicado: National Academy of Sciences 2017
Materias:
Biological Sciences
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5754810/
https://ncbi.nlm.nih.gov/pubmed/29203659
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1717005114
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