Neuropathy-causing TRPV4 mutations disrupt TRPV4-RhoA interactions and impair neurite extension

TRPV4 is a cell surface-expressed calcium-permeable cation channel that mediates cell-specific effects on cellular morphology and function. Dominant missense mutations of TRPV4 cause distinct, tissue-specific diseases, but the pathogenic mechanisms are unknown. Mutations causing peripheral neuropath...

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Publicado no:Nat Commun
Main Authors: McCray, Brett A., Diehl, Erika, Sullivan, Jeremy M., Aisenberg, William H., Zaccor, Nicholas W., Lau, Alexander R., Rich, Dominick J., Goretzki, Benedikt, Hellmich, Ute A., Lloyd, Thomas E., Sumner, Charlotte J.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2021
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7933254/
https://ncbi.nlm.nih.gov/pubmed/33664271
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-021-21699-y
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