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Structural basis of TRPV4 N-terminus interaction with Syndapin/PACSIN1-3 and PIP(2)
Transient Receptor Potential (TRP) channels are polymodally regulated ion channels. TRPV4 (vanilloid 4) is sensitized by PIP(2) and desensitized by Syndapin3/PACSIN3 which bind to the structurally uncharacterized TRPV4 N-terminus. We determined the NMR structure of the Syndapin3/PACSIN3 SH3 domain i...
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| Publicado no: | Structure |
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| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6281781/ https://ncbi.nlm.nih.gov/pubmed/30244966 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.str.2018.08.002 |
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