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Ketamine Metabolite (2R,6R)-Hydroxynorketamine Interacts with μ and κ Opioid Receptors
[Image: see text] Ketamine is an anesthetic, analgesic, and antidepressant whose secondary metabolite (2R,6R)-hydroxynorketamine (HNK) has N-methyl-d-aspartate-receptor-independent antidepressant activity in a rodent model. In humans, naltrexone attenuates its antidepressant effect, consistent with...
Gardado en:
| Publicado en: | ACS Chem Neurosci |
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| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
American Chemical
Society
2021
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| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8154314/ https://ncbi.nlm.nih.gov/pubmed/33905229 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschemneuro.0c00741 |
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