(R,S)-Ketamine metabolites (R,S)-norketamine and (2S,6S)-hydroxynorketamine increase the mammalian target of rapamycin (mTOR) function

BACKGROUND: Subanesthetic doses of (R,S)-ketamine are used in the treatment of neuropathic pain and depression. In the rat, the antidepressant effects of (R,S)-ketamine are associated with increased activity and function of mammalian target of rapamycin (mTOR); however, (R,S)-ketamine is extensively...

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Detaylı Bibliyografya
Asıl Yazarlar: Paul, Rajib K., Singh, Nagendra S., Khadeer, Mohammed, Moaddel, Ruin, Sanghvi, Mitesh, Green, Carol E, O’Loughlin, Kathleen, Torjman, Marc C., Bernier, Michel, Wainer, Irving W.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2014
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Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4061505/
https://ncbi.nlm.nih.gov/pubmed/24936922
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/ALN.0000000000000285
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