Stereoselective and regiospecific hydroxylation of ketamine and norketamine

1. The objective was to determine the cytochrome P450s (CYPs) responsible for the stereoselective and regiospecific hydroxylation of ketamine ((R,S)-Ket) to diastereomeric hydroxyketamines, (2S,6S;2R,6R)-HK (5a) and (2S,6R;2R,6S)-HK (5b) and norketamine ((R,S)-norKet) to hydroxynorketamines, (2S,6S;...

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Hlavní autoři: Desta, Zeruesenay, Moaddel, Ruin, Ogburn, Evan T., Xu, Cong, Ramamoorthy, Anuradha, Venkata, Swarajya Lakshmi Vattem, Sanghvi, Mitesh, Goldberg, Michael E., Torjman, Marc C., Wainer, Irving W.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2012
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3426663/
https://ncbi.nlm.nih.gov/pubmed/22612619
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3109/00498254.2012.685777
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