The distribution and clearance of (2S,6S)-hydroxynorketamine, an active ketamine metabolite, in Wistar rats

The distribution, clearance, and bioavailability of (2S,6S)-hydroxynorketamine has been studied in the Wistar rat. The plasma and brain tissue concentrations over time of (2S,6S)-hydroxynorketamine were determined after intravenous (20 mg/kg) and oral (20 mg/kg) administration of (2S,6S)-hydroxynork...

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Publicado en:Pharmacol Res Perspect
Autores principales: Moaddel, Ruin, Sanghvi, Mitesh, Dossou, Katina Sourou Sylvestre, Ramamoorthy, Anuradha, Green, Carol, Bupp, James, Swezey, Robert, O’Loughlin, Kathleen, Wainer, Irving W
Formato: Artigo
Lenguaje:Inglês
Publicado: John Wiley & Sons, Ltd 2015
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Original Articles
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4492732/
https://ncbi.nlm.nih.gov/pubmed/26171236
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/prp2.157
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