A parallel chiral-achiral liquid chromatographic method for the determination of the stereoisomers of ketamine and ketamine metabolites in the plasma and urine of patients with complex regional pain syndrome

A parallel chiral/achiral LC-MS/MS assay has been developed and validated to measure the plasma and urine concentrations of the enantiomers of ketamine, (R)- and (S)-Ket, in Complex Regional Pain Syndrome (CRPS) patients receiving a 5-day continuous infusion of a sub-anesthetic dose of (R,S)-Ket. Th...

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Main Authors: Moaddel, Ruin, Venkata, Swarajya Lakshmi Vattem, Tanga, Mary J., Bupp, James E., Green, Carol E., Iyer, Lalitha, Furimsky, Anna, Goldberg, Michael E., Torjman, Marc C., Wainer, Irving W.
Format: Artigo
Sprog:Inglês
Udgivet: 2010
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2948022/
https://ncbi.nlm.nih.gov/pubmed/20875593
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.talanta.2010.08.005
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