Simultaneous population pharmacokinetic modelling of ketamine and three major metabolites in patients with treatment-resistant bipolar depression

AIM: To construct a population pharmacokinetic (popPK) model for ketamine (Ket), norketamine (norKet), dehydronorketamine (DHNK), hydroxynorketamine (2S,6S;2R,6R)-HNK) and hydroxyketamine (HK) in patients with treatment-resistant bipolar depression. METHOD: Plasma samples were collected at 40, 80, 1...

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Hlavní autoři: Zhao, Xiaochen, Venkata, Swarajya Lakshmi Vattem, Moaddel, Ruin, Luckenbaugh, Dave A., Brutsche, Nancy E., Ibrahim, Lobna, Zarate, Carlos A., Mager, Donald E., Wainer, Irving W.
Médium: Artigo
Jazyk:Inglês
Vydáno: Blackwell Publishing Ltd 2012
Témata:
Pharmacokinetics
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3630750/
https://ncbi.nlm.nih.gov/pubmed/22295895
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2125.2012.04198.x
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