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What is hydroxynorketamine and what can it bring to neurotherapeutics?

(R,S)-Ketamine was initially developed as an anesthetic agent and its pharmacological properties were determined on the basis of this clinical use. However, pharmacological studies in rat led to the development of the ‘Ketamine Paradigm’, whereby (R,S)-ketamine and its N-demethylated metabolite (R,S...

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Detalhes bibliográficos
Publicado no:Expert Rev Neurother
Main Authors: Singh, Nagendra S, Zarate, Carlos A, Moaddel, Ruin, Bernier, Michel, Wainer, Irving W
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5990010/
https://ncbi.nlm.nih.gov/pubmed/25331415
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1586/14737175.2014.971760
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