Antidepressant-relevant concentrations of the ketamine metabolite (2R,6R)-hydroxynorketamine do not block NMDA receptor function

Preclinical studies indicate that (2R,6R)-hydroxynorketamine (HNK) is a putative fast-acting antidepressant candidate. Although inhibition of NMDA-type glutamate receptors (NMDARs) is one mechanism proposed to underlie ketamine’s antidepressant and adverse effects, the potency of (2R,6R)-HNK to inhi...

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Detaylı Bibliyografya
Yayımlandı:Proc Natl Acad Sci U S A
Asıl Yazarlar: Lumsden, Eric W., Troppoli, Timothy A., Myers, Scott J., Zanos, Panos, Aracava, Yasco, Kehr, Jan, Lovett, Jacqueline, Kim, Sukhan, Wang, Fu-Hua, Schmidt, Staffan, Jenne, Carleigh E., Yuan, Peixiong, Morris, Patrick J., Thomas, Craig J., Zarate, Carlos A., Moaddel, Ruin, Traynelis, Stephen F., Pereira, Edna F. R., Thompson, Scott M., Albuquerque, Edson X., Gould, Todd D.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: National Academy of Sciences 2019
Konular:
PNAS Plus
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC6421428/
https://ncbi.nlm.nih.gov/pubmed/30796190
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1816071116
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