Antidepressant-relevant concentrations of the ketamine metabolite (2R,6R)-hydroxynorketamine do not block NMDA receptor function

Preclinical studies indicate that (2R,6R)-hydroxynorketamine (HNK) is a putative fast-acting antidepressant candidate. Although inhibition of NMDA-type glutamate receptors (NMDARs) is one mechanism proposed to underlie ketamine’s antidepressant and adverse effects, the potency of (2R,6R)-HNK to inhi...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Julkaisussa:Proc Natl Acad Sci U S A
Päätekijät: Lumsden, Eric W., Troppoli, Timothy A., Myers, Scott J., Zanos, Panos, Aracava, Yasco, Kehr, Jan, Lovett, Jacqueline, Kim, Sukhan, Wang, Fu-Hua, Schmidt, Staffan, Jenne, Carleigh E., Yuan, Peixiong, Morris, Patrick J., Thomas, Craig J., Zarate, Carlos A., Moaddel, Ruin, Traynelis, Stephen F., Pereira, Edna F. R., Thompson, Scott M., Albuquerque, Edson X., Gould, Todd D.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: National Academy of Sciences 2019
Aiheet:
PNAS Plus
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC6421428/
https://ncbi.nlm.nih.gov/pubmed/30796190
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1816071116
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