(2R,6R)-hydroxynorketamine exerts mGlu(2) receptor-dependent antidepressant actions

Currently approved antidepressant drugs often take months to take full effect, and ∼30% of depressed patients remain treatment resistant. In contrast, ketamine, when administered as a single subanesthetic dose, exerts rapid and sustained antidepressant actions. Preclinical studies indicate that the...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Zanos, Panos, Highland, Jaclyn N., Stewart, Brent W., Georgiou, Polymnia, Jenne, Carleigh E., Lovett, Jacqueline, Morris, Patrick J., Thomas, Craig J., Moaddel, Ruin, Zarate, Carlos A., Gould, Todd D.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2019
Assuntos:
PNAS Plus
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6442605/
https://ncbi.nlm.nih.gov/pubmed/30867285
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1819540116
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