Hydroxynorketamines: Pharmacology and Potential Therapeutic Applications

Hydroxynorketamines (HNKs) are formed in vivo after (R,S)-ketamine (ketamine) administration. The 12 HNK stereoisomers are distinguished by the position of cyclohexyl ring hydroxylation (at the 4, 5, or 6 position) and their unique stereochemistry at two stereocenters. Although HNKs were initially c...

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Bibliografske podrobnosti
izdano v:Pharmacol Rev
Main Authors: Highland, Jaclyn N., Zanos, Panos, Riggs, Lace M., Georgiou, Polymnia, Clark, Sarah M., Morris, Patrick J., Moaddel, Ruin, Thomas, Craig J., Zarate, Carlos A., Pereira, Edna F. R., Gould, Todd D.
Format: Artigo
Jezik:Inglês
Izdano: The American Society for Pharmacology and Experimental Therapeutics 2021
Teme:
Review Articles
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC7938660/
https://ncbi.nlm.nih.gov/pubmed/33674359
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/pharmrev.120.000149
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