Hydroxynorketamines: Pharmacology and Potential Therapeutic Applications

Hydroxynorketamines (HNKs) are formed in vivo after (R,S)-ketamine (ketamine) administration. The 12 HNK stereoisomers are distinguished by the position of cyclohexyl ring hydroxylation (at the 4, 5, or 6 position) and their unique stereochemistry at two stereocenters. Although HNKs were initially c...

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Dettagli Bibliografici
Pubblicato in:Pharmacol Rev
Autori principali: Highland, Jaclyn N., Zanos, Panos, Riggs, Lace M., Georgiou, Polymnia, Clark, Sarah M., Morris, Patrick J., Moaddel, Ruin, Thomas, Craig J., Zarate, Carlos A., Pereira, Edna F. R., Gould, Todd D.
Natura: Artigo
Lingua:Inglês
Pubblicazione: The American Society for Pharmacology and Experimental Therapeutics 2021
Soggetti:
Review Articles
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7938660/
https://ncbi.nlm.nih.gov/pubmed/33674359
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/pharmrev.120.000149
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