Hydroxynorketamines: Pharmacology and Potential Therapeutic Applications

Hydroxynorketamines (HNKs) are formed in vivo after (R,S)-ketamine (ketamine) administration. The 12 HNK stereoisomers are distinguished by the position of cyclohexyl ring hydroxylation (at the 4, 5, or 6 position) and their unique stereochemistry at two stereocenters. Although HNKs were initially c...

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Опубликовано в: :Pharmacol Rev
Главные авторы: Highland, Jaclyn N., Zanos, Panos, Riggs, Lace M., Georgiou, Polymnia, Clark, Sarah M., Morris, Patrick J., Moaddel, Ruin, Thomas, Craig J., Zarate, Carlos A., Pereira, Edna F. R., Gould, Todd D.
Формат: Artigo
Язык:Inglês
Опубликовано: The American Society for Pharmacology and Experimental Therapeutics 2021
Предметы:
Review Articles
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC7938660/
https://ncbi.nlm.nih.gov/pubmed/33674359
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/pharmrev.120.000149
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