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Ketamine increases vmPFC activity: Effects of (R)- and (S)-stereoisomers and (2R,6R)- hydroxynorketamine metabolite
Ketamine, an NMDA receptor antagonist and fast acting antidepressant, produces a rapid burst of glutamate in the ventral medial prefrontal cortex (mPFC). Preclinical studies have demonstrated that pyramidal cell activity in the vmPFC is necessary for the rapid antidepressant response to ketamine in...
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| Publicado no: | Neuropharmacology |
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| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8073170/ https://ncbi.nlm.nih.gov/pubmed/31926944 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuropharm.2020.107947 |
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