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Integration of TGF-β-induced Smad signaling in the insulin-induced transcriptional response in endothelial cells

Insulin signaling governs many processes including glucose homeostasis and metabolism, and is therapeutically used to treat hyperglycemia in diabetes. We demonstrated that insulin-induced Akt activation enhances the sensitivity to TGF-β by directing an increase in cell surface TGF-β receptors from a...

詳細記述

保存先:
書誌詳細
出版年:Sci Rep
主要な著者: Budi, Erine H., Hoffman, Steven, Gao, Shaojian, Zhang, Ying E., Derynck, Rik
フォーマット: Artigo
言語:Inglês
出版事項: Nature Publishing Group UK 2019
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC6861289/
https://ncbi.nlm.nih.gov/pubmed/31740700
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-53490-x
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