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The insulin response integrates increased TGF-β signaling through Akt-induced enhancement of cell surface delivery of TGF-β receptors

Increased activity of transforming growth factor β (TGF-β), which binds to and stimulates cell surface receptors, contributes to cancer progression and fibrosis by driving epithelial cells toward a migratory mesenchymal phenotype and increasing the abundance of extracellular matrix proteins. The abu...

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Bibliographic Details
Published in:Sci Signal
Main Authors: Budi, Erine H., Muthusamy, Baby Periyanayaki, Derynck, Rik
Format: Artigo
Language:Inglês
Published: 2015
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4669960/
https://ncbi.nlm.nih.gov/pubmed/26420907
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scisignal.aaa9432
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