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Integration of TGF-β-induced Smad signaling in the insulin-induced transcriptional response in endothelial cells

Insulin signaling governs many processes including glucose homeostasis and metabolism, and is therapeutically used to treat hyperglycemia in diabetes. We demonstrated that insulin-induced Akt activation enhances the sensitivity to TGF-β by directing an increase in cell surface TGF-β receptors from a...

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Bibliografske podrobnosti
izdano v:Sci Rep
Main Authors: Budi, Erine H., Hoffman, Steven, Gao, Shaojian, Zhang, Ying E., Derynck, Rik
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group UK 2019
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6861289/
https://ncbi.nlm.nih.gov/pubmed/31740700
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-53490-x
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