HNRNPH1-dependent splicing of a fusion oncogene reveals a targetable RNA G-quadruplex interaction

The primary oncogenic event in ∼85% of Ewing sarcomas is a chromosomal translocation that generates a fusion oncogene encoding an aberrant transcription factor. The exact genomic breakpoints within the translocated genes, EWSR1 and FLI1, vary; however, in EWSR1, breakpoints typically occur within in...

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Vydáno v:RNA
Hlavní autoři: Neckles, Carla, Boer, Robert E., Aboreden, Nicholas, Cross, Allison M., Walker, Robert L., Kim, Bong-Hyun, Kim, Suntae, Schneekloth, John S., Caplen, Natasha J.
Médium: Artigo
Jazyk:Inglês
Vydáno: Cold Spring Harbor Laboratory Press 2019
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6859848/
https://ncbi.nlm.nih.gov/pubmed/31511320
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1261/rna.072454.119
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