Splicing factor hnRNPH drives an oncogenic splicing switch in gliomas

In tumours, aberrant splicing generates variants that contribute to multiple aspects of tumour establishment, progression and maintenance. We show that in glioblastoma multiforme (GBM) specimens, death-domain adaptor protein Insuloma-Glucagonoma protein 20 (IG20) is consistently aberrantly spliced t...

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Main Authors: LeFave, Clare V, Squatrito, Massimo, Vorlova, Sandra, Rocco, Gina L, Brennan, Cameron W, Holland, Eric C, Pan, Ying-Xian, Cartegni, Luca
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2011
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3209773/
https://ncbi.nlm.nih.gov/pubmed/21915099
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2011.259
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