EWS‐FLI1 reprograms the metabolism of Ewing sarcoma cells via positive regulation of glutamine import and serine‐glycine biosynthesis

Ewing sarcoma (EWS) is a soft tissue and bone tumor that occurs primarily in adolescents and young adults. In most cases of EWS, the chimeric transcription factor, EWS‐FLI1 is the primary oncogenic driver. The epigenome of EWS cells reflects EWS‐FLI1 binding and activation or repression of transcrip...

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Bibliografiske detaljer
Udgivet i:Mol Carcinog
Main Authors: Sen, Nirmalya, Cross, Allison M., Lorenzi, Philip L., Khan, Javed, Gryder, Berkley E., Kim, Suntae, Caplen, Natasha J.
Format: Artigo
Sprog:Inglês
Udgivet: John Wiley and Sons Inc. 2018
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Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6175245/
https://ncbi.nlm.nih.gov/pubmed/29873416
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/mc.22849
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