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HNRNPH1-dependent splicing of a fusion oncogene reveals a targetable RNA G-quadruplex interaction
The primary oncogenic event in ∼85% of Ewing sarcomas is a chromosomal translocation that generates a fusion oncogene encoding an aberrant transcription factor. The exact genomic breakpoints within the translocated genes, EWSR1 and FLI1, vary; however, in EWSR1, breakpoints typically occur within in...
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| Publicado no: | RNA |
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| Main Authors: | , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Cold Spring Harbor Laboratory Press
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6859848/ https://ncbi.nlm.nih.gov/pubmed/31511320 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1261/rna.072454.119 |
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